In the latest issue of PNAS, researchers report that drinking body-temperature blood causes mosquitoes to undergo a classic heat-shock response:
The mosquito’s body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti, we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito’s midgut.
Now we just need to develop some drug that will overload or exploit this response to prevent the mosquito from spreading disease. I’m imagining something like this: