Author Archives: Alan

TWiV 171: One is the loneliest number

Matt joins the TWiVarians to review virus production in single cells and single virion genomics. Links for this episode: H5N1 results will be published (NY Times) Virus production in single cells then and now Single virion genomics (PLoS One) Multiple displacement amplification (Wikipedia) Ranavirus killing turtles, tadpoles in Maryland … Continue reading

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TWiV 170: From variolous effluvia to VLPs

Alan, Rich, and Dickson discuss Edward Jenner’s paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more. Links for this episode: Norton Zinder, 83 (Reuters) Jenner’s cowpox vaccine paper (Bartleby, Gutenberg) Norovirus VLP vaccine (NEJM) … Continue reading

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Exploring the Sourdoughome

I love it when my interests intersect, so this new report from researchers in Italy and Belgium, on the microbiota of sourdough breads, definitely caught my attention. As the authors explain: This study aimed at the identification of the [lactic … Continue reading

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TWiV #170 – From variolous effluvia to VLPs

Alan, Rich, and Dickson discuss Edward Jenner’s paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more. Links for this episode: Norton Zinder, 83 (Reuters) Jenner’s cowpox vaccine paper (Bartleby, Gutenberg) Norovirus VLP vaccine (NEJM) … Continue reading

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TWiV 169: Epidemiology causes conclusions (p<0.05)

Michael and the TWiV team review epidemiology basics, including fatality ratios. Links for this episode: Michael’s blog and podcast Epidemiology literature critique (PowerPoint) Seven mistakes in epidemiology (ETE) Snow cholera map TWiV on Facebook Letters read on TWiV 169

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A Chat with Mike Osterholm

I got a call last night from Mike Osterholm, noted epidemiologist and member of the National Science Advisory Board for Biosecurity (NSABB). He wanted to talk about H5N1 flu – if you don’t know why, scroll down to the previous … Continue reading

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Some Unsolicited Debate Coaching for Tonight’s Speakers

The New York Academy of Sciences is hosting a panel discussion tonight about H5N1 influenza, “dual-use” research, and scientific censorship. Of course this stems from the ongoing debate about the alleged development of mammal-adapted H5N1 strains (see my earlier summaries … Continue reading

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TWiV 168: Super CalTech prophylaxis and ferret runny noses

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted. Links for this episode: Vectored HIV immunoprophylaxis (Nature) Vectored immunoprophylaxis - the Movie (YouTube) Adeno-associated virus (Wikipedia) In vitro evolution … Continue reading

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Who’s Afraid of the Big, Bad Bioterrorist?

The recent dustup about The H5N1 Bird Flu Plague That Will Kill Us All (not) has brought the topic of “bioterrorism” into the media spotlight again. This is an issue I’ve been following for several years, and during that time … Continue reading

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